Limbic-Predominant Age-Related TDP-43 Encephalopathy

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a cause of dementia that was discovered relatively recently. As the name implies, it tends to affect older people. The disease is progressive and shortens lifespan.

LATE can mimic Alzheimer’s disease or other causes of dementia, though it is thought to progress more slowly. Sometimes people have both LATE and Alzheimer’s disease, or LATE and another cause of dementia, and in those cases the progression may be more rapid.

A comprehensive evaluation by a specialist can lead to a diagnosis of dementia caused by LATE, however there is no biomarker test yet that can definitively prove this while a person is alive.

There is no cure for LATE, but there are many aspects of a person’s medical health, mental health, lifestyle, and environment that can be optimized to help slow progression of the disease.

References and Resources

  1. https://www.nia.nih.gov/health/what-limbic-predominant-age-related-tdp-43-encephalopathy-late
  2. https://alzheimer.ca/en/about-dementia/other-types-dementia/late-nc

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